7-Fluoro-2,3-dihydro-1h-indol-2-one → HCID 86706734, compound

HRID 1854776Notes

Reaction equation

HRID 1854776 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2.Cl[C:13]1[N:18]=[C:17]([O:19][CH3:20])[N:16]=[C:15]([CH3:21])[N:14]=1>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH:7]2[C:13]1[N:18]=[C:17]([O:19][CH3:20])[N:16]=[C:15]([CH3:21])[N:14]=1

Participants

3

Reactant 2

HCID 37343717-Fluoro-2,3-dihydro-1h-indol-2-oneHCID 193920792-Chloro-4-methoxy-6-methyl-1,3,5-triazine

Product 1

HCID 86706734HCID 86706734, compound

Procedure

7-Fluoro-1,3-dihydro-2H-indol-2-one (3.05 g) and 2-chloro-4-methoxy-6-methyl-1,3,5-triazine (6.59 g) are reacted analogously to Example 1 Variant A. This gives the title compound as solid in an HPLC purity of 85% area (4.73 g, 73% of theory).

Sources & evidence

ORD record
ord-dc1b5fa16e2a4d37a17fa070e75aace6
Source dataset
uspto-grants-2015_02
Patent number
US08962828B2

Reaction notes

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