Sodium Hydroxide → Laurolactam

HRID 1854781Notes

Reaction equation

HRID 1854781 reaction equation
[C:1]1(=[O:14])[NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(C)C=CC=CC=1.[OH-].[Na+]>O>[C:1]1(=[O:14])[NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86675543HCID 86675543, compound

Product 1

HCID 13690Laurolactam

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
85 °C

Procedure

50 g of water was added to 500 g of the laurolactam/toluene solution prepared by step C4 and the mixture was allowed to stand at 85° C. for 10 min and the phases were separated to obtain a light liquid phase. This operation was further repeated twice. To the light liquid phase obtained was added 64 g of a 1 mol/L aqueous sodium hydroxide solution, and the mixture was stirred at 85° C. for 10 min and then allowed to stand, followed by taking a light liquid phase (referred to as a post-treatment solution). The resulting light liquid phase was evaporated to remove toluene and then distilled (bottom temperature: 190° C., degree of vacuum: 3 to 4 torr, reflux ratio: 1, Sulzer packing: 7 plates) to give laurolactam.

Workup

  1. customthe phases were separated
  2. customto obtain a light liquid phase
  3. customTo the light liquid phase obtained
  4. customThe resulting light liquid phase was evaporated
  5. customto remove toluene
  6. distillationdistilled
  7. temperature(bottom temperature: 190° C., degree of vacuum: 3 to 4 torr, reflux ratio: 1, Sulzer packing: 7 plates)

Sources & evidence

ORD record
ord-f0ae29d81a894f5886ab11ae9ad369f0
Source dataset
uspto-grants-2015_02
Patent number
US08962826B2

Reaction notes

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