Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Barium hydroxide | HCID 6093286 | — |
| Reactant | Raltegravir | HCID 54671008 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 131732511 | HCID 131732511 | 82.5% |
Reaction Steps
Raltegravir (100 gm), ethanol (600 ml), acetonitrile (400 ml) and barium hydroxide (42 gm) were added at 25 to 30° C. The contents were heated to 60 to 65° C. to obtain a solution. The solution was cooled to 25 to 30° C. and stirred for 18 hours at 25 to 30° C. The solid obtained was collected by filtration and dried to obtain 108 gm of raltegravir barium.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08962833B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-5b67977b821f4db09e1cd56376775f11 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
