Methanol → HCID 67451161, compound

Participants

Reaction Conditions

Reaction Steps

Raltegravir (10 gm), methanol (60 ml), acetonitrile (40 ml), water (2 ml) and calcium acetate (4 gm) were added at 25 to 30° C. The contents were heated to 65 to 70° C. and distilled off solvent completely under vacuum at 45° C. to obtain residue. To the residue was added n-heptane (50 ml) and again distilled to obtain residue. n-Heptane (100 ml) was added to the residue and stirred for 6 hours at room temperature. The solid obtained was collected by filtration and dried to obtain 9.8 gm of raltegravir calcium.

Provenance & Evidence