3-(Methylsulfanyl)-1,2,4-triazine → HCID 86676670, compound

HRID 1854810Notes

Reaction equation

HRID 1854810 reaction equation
[CH3:1][CH:2]1[CH:7]([OH:8])[CH2:6][CH2:5][NH:4][CH2:3]1.CS[C:11]1[N:12]=[N:13][CH:14]=[CH:15][N:16]=1.N1(C2N=NC=CN=2)CCNCC1>>[CH3:1][CH:2]1[CH:7]([OH:8])[CH2:6][CH2:5][N:4]([C:11]2[N:12]=[N:13][CH:14]=[CH:15][N:16]=2)[CH2:3]1

Participants

4

Reactant 3

HCID 3218393-(Methylsulfanyl)-1,2,4-triazineHCID 4713502HCID 4713502, compoundHCID 12296696HCID 12296696, compound

Product 1

HCID 86676670HCID 86676670, compound

Procedure

Intermediate 5c is synthesised from 3-methyl-piperidin-4-ol and the precursor 2a according to the procedure described for the synthesis of 5a. Intermediate 5c is isolated in solid form with a 47% yield.

Sources & evidence

ORD record
ord-db563b6dc7174b8799c8c2acaf3de1da
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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