4-Hydroxypyrrolidine → HCID 86676671, compound

HRID 1854811Notes

Reaction equation

HRID 1854811 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]1.CS[C:9]1[N:10]=[N:11][CH:12]=[CH:13][N:14]=1.N1(C2N=NC=CN=2)CCNCC1>>[N:11]1[CH:12]=[CH:13][N:14]=[C:9]([N:1]2[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]2)[N:10]=1

Participants

4

Reactant 3

HCID 982104-HydroxypyrrolidineHCID 3218393-(Methylsulfanyl)-1,2,4-triazineHCID 12296696HCID 12296696, compound

Product 1

HCID 86676671HCID 86676671, compound

Procedure

Intermediate 5d is synthesised from pyrrolidin-3-ol and the precursor 2a according to the procedure described for the synthesis of 5a. Intermediate 5d is isolated in oil form with a 92% yield.

Sources & evidence

ORD record
ord-558312a588964d81bdae74b736062b24
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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