5-Fluoro-2-(trifluoromethyl)benzoyl chloride → HCID 53493384, compound

HRID 1854813Notes

Reaction equation

HRID 1854813 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[N:15]1([C:21]2[N:22]=[N:23][CH:24]=[CH:25][N:26]=2)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([C:7]([N:18]2[CH2:17][CH2:16][N:15]([C:21]3[N:22]=[N:23][CH:24]=[CH:25][N:26]=3)[CH2:20][CH2:19]2)=[O:8])[CH:10]=1.[N:23]1[CH:24]=[CH:25][N:26]=[C:21]([N:15]2[CH2:16][CH2:17][N:18]([C:7]([C:6]3[CH:10]=[CH:2][CH:3]=[CH:4][C:5]=3[C:11]([F:14])([F:13])[F:12])=[O:8])[CH2:19][CH2:20]2)[N:22]=1

Participants

4

Reactant 2

HCID 27375605-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 12296696HCID 12296696, compound

Product 2

HCID 53493384HCID 53493384, compoundYield 67%HCID 53493507HCID 53493507, compound

Procedure

Compound 4 is prepared from 5-fluoro-2-trifluoromethyl-benzoyl chloride and intermediate 5a according to synthesis method 2 under the operating conditions described for example 3 (67% yield).

Workup

  1. customaccording to synthesis method 2 under the operating conditions

Sources & evidence

ORD record
ord-bb572890c6424fc5a362df909fead99d
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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