Phenol, 2-chloro-5-(trifluoromethyl)- → HCID 53494319, compound

HRID 1854815Notes

Reaction equation

HRID 1854815 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[OH:12].[CH3:13][CH:14]1[CH:19](O)[CH2:18][CH2:17][N:16]([C:21]2[N:22]=[N:23][CH:24]=[CH:25][N:26]=2)[CH2:15]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:11])[F:9])=[CH:4][C:3]=1[O:12][CH:19]1[CH2:18][CH2:17][N:16]([C:21]2[N:22]=[N:23][CH:24]=[CH:25][N:26]=2)[CH2:15][CH:14]1[CH3:13]

Participants

3

Reactant 2

HCID 123498Phenol, 2-chloro-5-(trifluoromethyl)-HCID 86676670HCID 86676670, compound

Product 1

HCID 53494319HCID 53494319, compound

Procedure

Compound 37 is prepared from 2-chloro-5-trifluoromethylphenol and intermediate 5c according to synthesis method 3 under the operating conditions described for example 8 (38% yield).

Workup

  1. customaccording to synthesis method 3 under the operating conditions

Sources & evidence

ORD record
ord-9a4cc1abf1554e9ea799a1904c5e2596
Source dataset
uspto-grants-2015_02
Patent number
US08962837B2

Reaction notes

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