huagongshe.com
HRID1854832

反应详情

EQUATION

反应方程式

HRID 1854832 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2ccc(N)cc2F)OC1(C)C
HCID44755207

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

C12H17BFNO2

结构：COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O
HCID86696543

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(N)cc3F)ccn2c1=O
HCID86696550

未命名化合物

收率 69.8%

PROCEDURE

实验过程

Methyl 8-(4-amino-2-fluoro-phenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A using methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (100 mg, 0.34 mmol) and 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline (122 mg, 0.51 mmol). Purification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6) afforded the title compound as a yellow solid (87 mg, 64%). ESI-MS m/z: 367 (M+H)+.

WORKUP

后处理

  1. customMethyl 8-(4-amino-2-fluoro-phenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared
  2. customPurification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6)