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HRID1854840

反应详情

EQUATION

反应方程式

HRID 1854840 的结构方程式

REACTANTS

反应物

2
结构：CNc1ccc(B2OC(C)(C)C(C)(C)O2)cc1
HCID11957892

N-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

C13H20BNO2

结构：COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O
HCID86696543

未命名化合物

PRODUCTS

生成物

1
结构：CNc1ccc(-c2ccn3c(=O)c(C(=O)OC)cc(C4CC4)c3c2C)cc1
HCID86696558

未命名化合物

收率 89.4%

PROCEDURE

实验过程

Methyl 1-cyclopropyl-9-methyl-8-(4-(methylamino)-phenyl)-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A using methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (74 mg, 0.25 mmol) and N-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline (71 mg, 0.31 mmol). Purification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6) afforded the title compound as a yellow solid (81 mg, 81%). ESI-MS m/z: 363 (M+H)+.

WORKUP

后处理

  1. customMethyl 1-cyclopropyl-9-methyl-8-(4-(methylamino)-phenyl)-4-oxo-4H-quinolizine-3-carboxylate was prepared
  2. customPurification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6)