HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Cyano-3-fluorophenyl)boronic acid → HCID 86696574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Cyano-3-fluorophenyl)boronic acid | HCID 2783130 | — |
| Reactant | Methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-quinolizine-3-carboxylate | HCID 86696543 | — |
| Product | HCID 86696574 | HCID 86696574 | 105.5% |
Reaction Steps
Methyl 8-(4-cyano-3-fluoro-phenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A using methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (100 mg, 0.34 mmol) and 4-cyano-3-fluoro-phenyl-boronic acid (85 mg, 0.51 mmol). Purification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6) afforded the title compound as a yellow solid (135 mg, 98%). ESI-MS m/z: 377 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962842B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-803c692c6ce847adad5ec0ef28de1095 |
| Source note | uspto-grants-2015_02 |