2-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethanol → 3-(1-(3-Phenoxyphenyl)-2-oxabicyclo[2.2.2]octan-4-yl)propanal

関与物質

反応手順

3-(1-(3-Phenoxyphenyl)-2-oxabicyclo[2.2.2]octan-4-yl)propanal (clear oil) was prepared using a procedure analogous to 3-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)propanal except that 2-(1-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethanol was replaced with 2-(1-(3-phenoxyphenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethanol. LCMS, [M−H]+=335.2. 1H NMR (500 MHz, CDCl3) δ 9.78 (t, J=1.5 Hz, 1H), 7.34-7.23 (m, 3H), 7.14-7.03 (m, 3H), 7.01-6.95 (m, 2H), 6.87-6.81 (m, 1H), 3.81-3.78 (m, 2H), 2.43-2.36 (m, 2H), 2.09-1.94 (m, 4H), 1.69-1.58 (m, 4H), 1.54-1.47 (m, 2H).

情報源と証拠