p-Toluenesulfonic acid monohydrate → HCID 90408509, compound

Participants

Reaction Steps

To a solution of (6-(3-phenoxyphenyl)-1-oxaspiro[2.5]octan-6-yl)methanol (55.9 mg, 0.180 mmol) in CH2Cl2 (2 mL) at 0° C. was added p-toluenesulfonic acid monohydrate (3.43 mg, 0.018 mmol). The solution was warmed to rt and stirred for 1 h. The reaction was then diluted with EtOAc, washed successively with sat'd aq NaHCO3, water, and brine, dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by flash chromatography on SiO2 (0 to 100% EtOAc:hexanes) to afford the title compound (15 mg, 27% yield) as an oil. LCMS, [M+Na]+=333.0.

Provenance & Evidence