Methanesulfonyl chloride → HCID 90408426, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonyl chloride (0.100 mL, 1.28 mmol) was added to a solution of 2-(1-(3-fluoro-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)ethanol (36G; 0.373 g, 1.06 mmol) and TEA (0.46 mL. 3.19 mmol) in DCM (5 mL) at 0° C. and the reaction was stirred at 0° C. for 2 h and then concentrated in vacuo. The residue was dissolved in EtOAc (50 mL), washed with 1 N aq. HCl and water, sat. aq. NaHCO3, and water again. The organic layer was dried (MgSO4) and filtered. The filtrate was concentrated in vacuo to give the crude title compound (0.456 g, 1.06 mmol, 100% yield) as a clear oil.

Provenance & Evidence