反应详情

Example 115 was synthesized using the same 2-step protocol as for the syntheses of Examples 39-45 from intermediate phenol 7F, but with 6-methylpyridin-3-ylboronic acid. LCMS, [M−H]+=396.2. 1H NMR (500 MHz, DMSO-d6) δ=8.18 (br. s, 1H), 7.35-7.25 (m, 3H), 7.11 (d, J=7.3 Hz, 1H), 7.00 (br. s, 1H), 6.83 (d, J=7.6 Hz, 1H), 3.95 (s, 2H), 3.58-3.43 (m, 2H), 2.44 (s, 3H), 2.06-1.96 (m, 2H), 1.81-1.72 (m, 2H), 1.68-1.54 (m, 4H), 1.40-1.34 (m, 2H), 1.28-1.20 (m, 2H).

1. customExample 115 was synthesized