1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-isopropylisoxazol-5-yl)urea → 1-(3-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy)phenyl)-3-(3-(tetrahydro-2H-pyran-4-yl)isoxazol-5-yl)urea
Reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:18][c:19]3[cH:20][c:21]([NH2:22])[cH:23][cH:24][cH:25]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH2:14][CH2:15][O:16][CH3:17].[CH3:47][O:48][c:49]1[cH:50][c:51]2[c:52]([cH:53][c:54]1[O:55][CH3:56])[n:57][cH:58][n:59][c:60]2[O:61][c:62]1[cH:63][c:64]([NH:65][C:66]([NH:67][c:68]2[o:69][n:70][c:71]([CH:72]([CH3:73])[CH3:74])[cH:75]2)=[O:76])[cH:77][cH:78][cH:79]1.[O:26]1[CH2:27][CH2:28][CH:29]([c:32]2[n:33][o:34][c:35]([NH:37][C:38]([O:39][c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)=[O:40])[cH:36]2)[CH2:30][CH2:31]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:18][c:19]3[cH:20][c:21]([NH:22][C:38]([NH:37][c:35]4[o:34][n:33][c:32]([CH:29]5[CH2:28][CH2:27][O:26][CH2:31][CH2:30]5)[cH:36]4)=[O:39])[cH:23][cH:24][cH:25]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH2:14][CH2:15][O:16][CH3:17]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e0490e3af9134828b26f884e73c4bf8b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
Loading…