2-Cyano-6-methoxy benzothiazole → 2-Cyano-6-hydroxybenzothiazole

HRID 1855204Notes

Reaction equation

[C:1]([C:3]1[S:4][C:5]2[CH:11]=[C:10]([O:12]C)[CH:9]=[CH:8][C:6]=2[N:7]=1)#[N:2].Cl.N1C=CC=CC=1>>[C:1]([C:3]1[S:4][C:5]2[CH:11]=[C:10]([OH:12])[CH:9]=[CH:8][C:6]=2[N:7]=1)#[N:2]

Participants

Reactant 2

HCID 3421092-Cyano-6-methoxy benzothiazole

HCID 10176127Pyridinium chloride

Product 1

HCID 98819122-Cyano-6-hydroxybenzothiazole

Procedure

In greater detail, 2-cyano-6-methoxybenzothiazole is used as a starting material and reacted with pyridine hydrochloride to yield 2-cyano-6-hydroxybenzothiazole. Next, the 2-cyano-6-hydroxybenzothiazole is reacted with allyl bromide to yield 6-allyloxy-benzothiazole-2-carbonitrile.

Sources & evidence

ORD record: ord-a5b8fd71deca450fa6306c2ec9b2d61c
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962854B2

Reaction notes

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