反应详情

To a 2 L three-necked round-bottom flask fitted with a mechanical stirrer was added bromopinacolone A-1 (134 g, 747 mmol, 1.0 equiv), acetone (1.2 L), and sodium azide (63.2 g, 971 mmol, 1.3 equiv). The reaction mixture was stirred at room-temperature overnight and then filtered, and the solids were washed with acetone (2×100 mL). The filtrate was concentrated in vacuo to provide azidopinacolone (105.0 g, 100%) as an oil. The crude material was used in the next step without further purification.

1. customTo a 2 L three-necked round-bottom flask fitted with a mechanical stirrer
2. filtrationfiltered
3. washthe solids were washed with acetone (2×100 mL)
4. concentrationThe filtrate was concentrated in vacuo