Methanol → Methyl 2-(4-aminophenyl)acetate

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-aminophenyl)acetic acid (B−1) (10 g, 66.16 mmol) in methanol (50 mL) was added dropwise SOCl2 (5 mL). The mixture was stirred at 60° C. for 6 h. After evaporated the solvent, the residue was recrystallized with Et2O to afford the product (10.9 g, 99%) as a yellow solid. LC-MS: (M+H)+=166;

Provenance & Evidence