Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Chloropyridine-2-carbonitrile | HCID 818258 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-(4-Bromophenoxy)picolinonitrile | HCID 66728134 | — |
Reaction Steps
A RBF was charged with 3-chloro-2-cyanopyridine (40 g, 289 mmol), 4-bromophenol (49.9 g, 289 mmol) and cesium carbonate (113 g, 346 mmol). The reactants were suspended in 50 mL of DMSO and allowed to stir at 85° C. overnight. The reaction was cooled to RT and 600 mL of water was added to it. The reaction was filtered and the solid washed with water, then air dried to provide 3-(4-bromophenoxy)-picolinonitrile as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08962859B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-7cef60b01e52408ba3542f69a494d034 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
