Potassium Carbonate → HCID 60164215, compound

Participants

Reaction Conditions

Reaction Steps

A pressure vessel was charged with potassium carbonate (1M solution) (49 mL, 49 mmol), bis(di-tert-butyl(4-dimethylaminophenyl)phospine)dichloropalladium(II) (1.739 g, 2.457 mmol), 2-fluoropyridin-3-ylboronic acid (3.46 g, 24.57 mmol), and 7′-bromo-4′-fluoro-2′-methoxyspiro[imidazo[1,5-a]imidazole-7,9′-xanthen]-5-amine (5.1 g, 12.28 mmol). Dioxane (150 mL) was added and the mixture was capped under argon, sonicated for 1 min and heated at 100° C. for 4 hours. The solution was concentrated. Material was purified via silica gel column chromatography using 50-100% ethyl acetate in hexane to afford 4′-fluoro-7′-(2-fluoropyridin-3-yl)-2′-methoxyspiro[imidazo[1,5-a]imidazole-7,9′-xanthen]-5-amine (3 g, 6.95 mmol) as a white solid.

Provenance & Evidence