Potassium Carbonate → HCID 68282946, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (1M aq. Solution) (1.391 mL, 1.391 mmol), 2-fluoropyridin-3-ylboronic acid (98 mg, 0.696 mmol), bis(di-tert-butyl(4-dimethylaminophenyl)phospine)dichloropalladium(II) (0.34 mmol) and 7′-bromo-4′-fluoro-2′-methoxy-3,4-dihydro-2H-spiro[imidazo[1,5-a]pyrimidine-8,9′-xanthen]-6-amine (150 mg, 0.348 mmol) were combined in dioxane (3 mL), capped under argon, and heated at 100° C. for 2 hours. The solution was concentrated, and the product was purified from the crude concentrate via silica gel column chromatography (RediSep 12 g column) using 0-100% 90/10/1 (DCM/MeOH/ammonia) in DCM to afford 4′-fluoro-7′-(2-fluoropyridin-3-yl)-2′-methoxy-3,4-dihydro-2H-spiro[imidazo[1,5-a]pyrimidine-8,9′-xanthen]-6-amine (30 nig, 0.067 mmol). MS m/z=449.2 [M+H].

Provenance & Evidence