Potassium Phosphate, Tribasic → HCID 86711701, compound

Participants

Reaction Steps

To a flask containing ethanol and (R)-1-{4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-hexyl]-phenyl}-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester was added aqueous potassium phosphate bibasic followed by an aqueous solution of sodium borohydride, while maintaining the reaction at ambient temperature (˜23° C.). The mixture was stirred at ambient temperature until all of the ethyl ester was consumed before quenching with water, and then extracted with MTBE. The combined organic extracts were washed with brine and concentrated under reduced pressure to give crude product as an off-white solid. The crude product was re-crystallized with heptanes to give a pure product.

Provenance & Evidence