3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline → HCID 44192501, compound

HRID 1855327Notes

Reaction equation

HRID 1855327 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[F:16][C:17]1[CH:18]=[C:19]([CH:28]=[C:29]([F:32])[C:30]=1[F:31])[CH2:20][C:21]1[CH:26]=[CH:25][N:24]=[C:23](Cl)[N:22]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:23]2[N:22]=[C:21]([CH2:20][C:19]3[CH:18]=[C:17]([F:16])[C:30]([F:31])=[C:29]([F:32])[CH:28]=3)[CH:26]=[CH:25][N:24]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)anilineHCID 86633614HCID 86633614, compound

Product 1

HCID 44192501HCID 44192501, compoundYield 54%

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 4-(3,4,5-trifluoro-benzyl)-2-chloro-pyrimidine. It was obtained as a pale-brown solid in 54% yield.

Workup

  1. customIt was obtained as a pale-brown solid in 54% yield

Sources & evidence

ORD record
ord-32f5faef274b409d8cd54010dcbec86d
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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