tert-Butoxy bis(dimethylamino)methane → 1-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one

Participants

Reaction Steps

A mixture of 2-phenyl-3-pentanone (106 mg, 0.54 mmol) and of tert.-butoxy-bis(dimethylamino)methane (146 mg, 0.75 mmol, 90%) was stirred at 110° C. for 16 h. The reaction was evaporated to dryness, treated twice with toluene and the solvent was evaporated under reduced pressure to give the crude title compound (138 mg, 97%) as a dark brown solid which was used directly in the next step without further purification.

Provenance & Evidence