3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline → [4-(2,6-Dichloro-phenoxy)-pyrimidin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

HRID 1855338Notes

Reaction equation

HRID 1855338 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[CH:22]=[C:21]([O:23][C:24]2[C:29]([Cl:30])=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:31])[N:20]=[CH:19][N:18]=1>>[Cl:31][C:25]1[CH:26]=[CH:27][CH:28]=[C:29]([Cl:30])[C:24]=1[O:23][C:21]1[CH:22]=[CH:17][N:18]=[C:19]([NH:15][C:5]2[CH:6]=[CH:7][C:8]([N:9]3[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[N:20]=1

Participants

3

Reactant 2

HCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)anilineHCID 86633617HCID 86633617, compound

Product 1

HCID 44192599[4-(2,6-Dichloro-phenoxy)-pyrimidin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amineYield 29%

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 4-chloro-6-(2,6-dichloro-phenoxy)-pyrimidine. It was obtained as a yellow solid in 29% yield.

Workup

  1. customIt was obtained as a yellow solid in 29% yield

Sources & evidence

ORD record
ord-c72a1c10f3814f91bd58ed9ff4477587
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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