3,4-Difluorophenol → HCID 44192597, compound

HRID 1855339Notes

Reaction equation

HRID 1855339 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].Cl[C:11]1[CH:16]=[C:15]([CH3:17])[N:14]=[C:13]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]3)=[C:21]([O:31][CH3:32])[CH:20]=2)[N:12]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[O:9][C:11]1[CH:16]=[C:15]([CH3:17])[N:14]=[C:13]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]3)=[C:21]([O:31][CH3:32])[CH:20]=2)[N:12]=1

Participants

3

Reactant 2

HCID 759273,4-DifluorophenolHCID 57829826HCID 57829826, compound

Product 1

HCID 44192597HCID 44192597, compoundYield 81%

Procedure

The title compound was prepared in analogous manners as described in example 9) from 3,4-difluorophenol and (4-chloro-6-methyl-pyrimidin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. It was obtained in 81% yield as a pale-brown solid.

Workup

  1. customIt was obtained in 81% yield as a pale-brown solid

Sources & evidence

ORD record
ord-eb09b00d4d384e16828ef576156849d5
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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