3-Hydroxypyridine → N-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4-methyl-6-(3-pyridinyloxy)-2-pyrimidinamine

Participants

Reaction Steps

The title compound was prepared in analogous manners as described in example 9 from 3-hydroxy-pyridine and (4-chloro-6-methyl-pyrimidin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. It was obtained in 53% yield as a pale-yellow solid after purification by column chromatography on silica gel using dichloromethane/methanol (19:1 v/v) as eluent.

Provenance & Evidence