3-(Trifluoromethoxy)phenol → HCID 44192601, compound

HRID 1855344Notes

Reaction equation

HRID 1855344 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1.Cl[C:14]1[CH:19]=[C:18]([CH3:20])[N:17]=[C:16]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]3)=[C:24]([O:34][CH3:35])[CH:23]=2)[N:15]=1>>[CH3:35][O:34][C:24]1[CH:23]=[C:22]([NH:21][C:16]2[N:17]=[C:18]([CH3:20])[CH:19]=[C:14]([O:10][C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:11])([F:12])[F:1])[CH:5]=3)[N:15]=2)[CH:27]=[CH:26][C:25]=1[N:28]1[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]1

Participants

3

Reactant 2

HCID 27332613-(Trifluoromethoxy)phenolHCID 57829826HCID 57829826, compound

Product 1

HCID 44192601HCID 44192601, compoundYield 95%

Procedure

The title compound was prepared in analogous manners as described in example 9 from 3-trifluoromethoxy-phenol and (4-chloro-6-methyl-pyrimidin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. It was obtained in 95% yield as a pale-brown solid. MS ISP (m/e): 472.0 (100) [(M+H)+].

Workup

  1. customIt was obtained in 95% yield as a pale-brown solid

Sources & evidence

ORD record
ord-f4c739d8f1764e1ba178ba1a856af7bb
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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