3-(Trifluoromethyl)phenol → HCID 44192987, compound

HRID 1855345Notes

Reaction equation

HRID 1855345 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.Cl[C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]3)=[C:23]([O:33][CH3:34])[CH:22]=2)[N:14]=1>>[CH3:34][O:33][C:23]1[CH:22]=[C:21]([NH:20][C:15]2[N:16]=[C:17]([CH3:19])[CH:18]=[C:13]([O:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=3)[N:14]=2)[CH:26]=[CH:25][C:24]=1[N:27]1[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]1

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 57829826HCID 57829826, compound

Product 1

HCID 44192987HCID 44192987, compoundYield 62%

Procedure

The title compound was prepared in analogous manners as described in example 9 from 3-trifluoromethyl-phenol and (4-chloro-6-methyl-pyrimidin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. It was obtained in 62% yield as a pale-yellow viscous oil.

Workup

  1. customIt was obtained in 62% yield as a pale-yellow viscous oil

Sources & evidence

ORD record
ord-40f96ffb60534350b67e88e35c831c63
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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