Triethylamine → {4-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-pyrimidin-2-yl}-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Participants

Reaction Steps

The title compound was prepared in analogous manner as described in example 4c) from N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]guanidine dinitrate and 4-(4-chloro-phenyl)-1-dimethylamino-4-methyl-pent-1-en-3-one, and triethylamine using 1-methyl-2-pyrrolidone as solvent. The reaction was performed in a microwave oven at 200° C. for 2 h. The title compound was isolated as a brown solid in 20% yield.

Provenance & Evidence