1-Dimethylamino-4-methyl-4-(3,4,5-trifluoro-phenyl)-pent-1-en-3-one → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-{4-[1-methyl-1-(3,4,5-trifluoro-phenyl)-ethyl]-pyrimidin-2-yl}-amine

HRID 1855353Notes

Reaction equation

HRID 1855353 reaction equation
[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([NH:23][C:24]([NH2:26])=[NH:25])[CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1.CN(C)[CH:29]=[CH:30][C:31](=O)[C:32]([CH3:43])([C:34]1[CH:39]=[C:38]([F:40])[C:37]([F:41])=[C:36]([F:42])[CH:35]=1)[CH3:33]>>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([NH:23][C:24]2[N:26]=[C:31]([C:32]([CH3:43])([C:34]3[CH:35]=[C:36]([F:42])[C:37]([F:41])=[C:38]([F:40])[CH:39]=3)[CH3:33])[CH:30]=[CH:29][N:25]=2)[CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1

Participants

3

Reactant 2

HCID 686328491-Dimethylamino-4-methyl-4-(3,4,5-trifluoro-phenyl)-pent-1-en-3-oneHCID 178493228HCID 178493228, compound

Product 1

HCID 57829781[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-{4-[1-methyl-1-(3,4,5-trifluoro-phenyl)-ethyl]-pyrimidin-2-yl}-amineYield 21%

Procedure

The title compound was prepared in analogous manner as described in example 4c) from N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]guanidine dinitrate and 1-dimethylamino-4-methyl-4-(3,4,5-trifluoro-phenyl)-pent-1-en-3-one as a pale-brown solid in 21% yield.

Sources & evidence

ORD record
ord-f8e41353dc5a4822a2164e9576fdbe3d
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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