2-Chloro-4-(trifluoromethyl)pyrimidine → HCID 57829730, compound

HRID 1855355Notes

Reaction equation

HRID 1855355 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][N:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:17]2[N:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][N:18]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829730HCID 57829730, compound

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 2-chloro-4-trifluoromethyl-pyrimidine. The reaction was refluxed for 16 h. The title compound was obtained as a pale-yellow solid in 43% yield.

Workup

  1. customThe title compound was prepared in analogous manner
  2. temperatureThe reaction was refluxed for 16 h

Sources & evidence

ORD record
ord-3d64d1d6a813462ea1cc1db9999bb37f
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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