Methyl 2-chloro-6-methylpyrimidine-4-carboxylate → HCID 57829739, compound

HRID 1855357Notes

Reaction equation

HRID 1855357 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[CH:20]=[C:19]([CH3:27])[N:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:17]2[N:22]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[CH:20]=[C:19]([CH3:27])[N:18]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylateHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829739HCID 57829739, compound

Procedure

The title compound was prepared in analogous manner as described in example 1e) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and methyl 2-chloro-6-methyl-pyrimidine-4-carboxylate. The reaction was heated to reflux for 16 h. The title compound was obtained as a pale-brown solid in 18% yield.

Workup

  1. customThe title compound was prepared in analogous manner
  2. temperatureThe reaction was heated
  3. temperatureto reflux for 16 h

Sources & evidence

ORD record
ord-c92d28c65abe4b9d9e629e60a1602cb5
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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