4,4,4-Trifluoro-1-(4-pyrazol-1-yl-phenyl)-butane-1,3-dione → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[4-(4-pyrazol-1-yl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-amine

HRID 1855362Notes

Reaction equation

HRID 1855362 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3](=O)[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]([NH2:46])=[NH:45])[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1>>[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]2[N:45]=[C:5]([C:7]3[CH:12]=[CH:11][C:10]([N:13]4[CH:17]=[CH:16][CH:15]=[N:14]4)=[CH:9][CH:8]=3)[CH:4]=[C:3]([C:2]([F:20])([F:19])[F:1])[N:46]=2)[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1

Participants

3

Reactant 2

HCID 686309374,4,4-Trifluoro-1-(4-pyrazol-1-yl-phenyl)-butane-1,3-dioneHCID 178493228HCID 178493228, compound

Product 1

HCID 57829758[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[4-(4-pyrazol-1-yl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-amine

Procedure

The title compound was prepared from 4,4,4-trifluoro-1-(4-pyrazol-1-yl-phenyl)-butane-1,3-dione (137 mg, 0.0.49 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (180 mg, 0.49 mmol) using in analogous manner the procedure described in example 29). Obtained as a pale-yellow solid (25 mg, 10%). Mp 252-254° C.

Sources & evidence

ORD record
ord-dd8867a6e3e242e3ae6fe0407185ee95
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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