Ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate → Ethyl 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-4-(4-trifluoromethyl-phenyl)-pyrimidine-5-carboxylate

Participants

Reaction Steps

The title compound was prepared from ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate (151 mg, 0.48 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (133 mg, 0.36 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (14 mg, 6%).

Provenance & Evidence