tert-Butoxy bis(dimethylamino)methane → HCID 68631884, compound

HRID 1855365Notes

Reaction equation

HRID 1855365 reaction equation
[O:1]=[C:2]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[N:16])[CH:10]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O[CH:22](N(C)C)[N:23]([CH3:25])[CH3:24])(C)(C)C>>[CH3:22][N:23]([CH3:25])[CH:24]=[C:3]([C:2](=[O:1])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]#[N:16])[CH:10]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 11622629Ethyl 3-(3-cyanophenyl)-3-oxopropanoate

Product 1

HCID 68631884HCID 68631884, compound

Procedure

Ethyl 3-oxo-3-(3-cyano-phenyl)-propionate (109 mg, 0.5 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (85 mg) as a yellow oil which was used directly in the next step.

Sources & evidence

ORD record
ord-aa7239e6451048419ad631aef4e13e4d
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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