tert-Butoxy bis(dimethylamino)methane → HCID 68631010, compound

HRID 1855367Notes

Reaction equation

HRID 1855367 reaction equation
[O:1]=[C:2]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH:3]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O[CH:27](N(C)C)[N:28]([CH3:30])[CH3:29])(C)(C)C>>[CH2:7]([O:6][C:4](=[O:5])[CH:3]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:2](=[O:1])[C:15]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[CH:27][N:28]([CH3:30])[CH3:29])[CH3:8]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 95325Ethyl β-oxo-α-phenylbenzenebutanoate

Product 1

HCID 68631010HCID 68631010, compound

Procedure

Ethyl 3-oxo-2,4-diphenyl-butyrate (76 mg, 0.3 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (102 mg) as a red oil which was used directly in the next step.

Sources & evidence

ORD record
ord-06d2c9300315422da68732051ff65281
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

Loading…