HCID 54513699, compound → HCID 57829866, compound

HRID 1855370Notes

Reaction equation

HRID 1855370 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8](=[CH:14]N(C)C)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=O)=[C:4]([Cl:20])[CH:3]=1.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]([NH2:46])=[NH:45])[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]2[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:14][N:46]=[C:44]([NH:43][C:33]3[CH:34]=[CH:35][C:36]([N:37]4[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]4)=[C:31]([O:30][CH3:29])[CH:32]=3)[N:45]=2)=[C:4]([Cl:20])[CH:3]=1

Participants

3

Reactant 2

HCID 54513699HCID 54513699, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57829866HCID 57829866, compoundYield 28%

Procedure

The title compound was prepared from crude ethyl 2-(4-bromo-2-chloro-benzoyl)-3-dimethylamino-acrylate (50 mg, 0.14 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (43 mg, 0.12 mmol) using in analogous manner the procedure described in example 28b). Obtained as a yellow solid (50 mg) in 28% yield.

Sources & evidence

ORD record
ord-202097bf61cb4a4e82f13d8c7b6ceb34
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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