Ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate → Ethyl 2-[3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenylamino]-4-(4-fluoromethyl-phenyl)-pyrimidine-5-carboxylate

Participants

Reaction Steps

The title compound was prepared from crude ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate (142 mg, 0.45 mmol) and N-[3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (121 mg, 0.34 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (128 mg, 78%). Mp 219-221° C.

Provenance & Evidence