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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1855379Generated: October 26, 2026

3-fluoro-4-(2-methyl-1H-imidazol-1-yl)aniline → (4-Benzyl-6-methyl-pyrimidin-2-yl)-[3-fluoro-4-(2-methyl-imidazol-1-yl)-phenyl]-amine

https://huagongshe.com/reaction/1855379

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-fluoro-4-(2-methyl-1H-imidazol-1-yl)anilineHCID 21876620—
Reactant4-Benzyl-2-chloro-6-methyl-pyrimidineHCID 86633618—
Product(4-Benzyl-6-methyl-pyrimidin-2-yl)-[3-fluoro-4-(2-methyl-imidazol-1-yl)-phenyl]-amineHCID 57829796—

Reaction Steps

The title compound was prepared from 3-fluoro-4-(2-methyl-imidazol-1-yl)-phenylamine (87 mg, 0.46 mmol) and 4-benzyl-2-chloro-6-methyl-pyrimidine (100 mg, 0.46 mmol) in analogous manner to the procedure described in example 1e). Obtained as a light yellow oil (140 mg, 82%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08962834B2
Source datasetuspto-grants-2015_02
ORD IDord-ceede4dd4ae14ee4a70b3f5f44c8015a
Source noteuspto-grants-2015_02