Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1855380Generated: October 27, 2026

3-fluoro-4-(1H-imidazol-1-yl)aniline → (4-Benzyl-6-methyl-pyrimidin-2-yl)-(3-fluoro-4-imidazol-1-yl-phenyl)-amine

https://huagongshe.com/reaction/1855380

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-fluoro-4-(1H-imidazol-1-yl)anilineHCID 10374976—
Reactant4-Benzyl-2-chloro-6-methyl-pyrimidineHCID 86633618—
Product(4-Benzyl-6-methyl-pyrimidin-2-yl)-(3-fluoro-4-imidazol-1-yl-phenyl)-amineHCID 57829733—

Reaction Steps

The title compound was prepared from 3-fluoro-4-imidazol-1-yl-phenylamine (81 mg, 0.46 mmol) and 4-benzyl-2-chloro-6-methyl-pyrimidine (100 mg, 0.46 mmol) in analogous manner to the procedure described in example 1e). Obtained as a light yellow wax (40 mg, 24%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08962834B2
Source datasetuspto-grants-2015_02
ORD IDord-25c76da6f1cd4919b385dc9167c09228
Source noteuspto-grants-2015_02