HCID 68629712, compound → HCID 68911546, compound

Participants

Reaction Steps

A suspension of 5-(2-methoxy-4-nitro-phenyl)-thiazole (160 mg, 0.68 mmol and stannous dichloride (655 mg, 3.39 mmol) in ethanol (10 mL) was stirred at reflux temperature for 75 min. The yellow solution was evaporated under reduced pressure and the residue was dissolved in ethyl acetate. This solution is washed successively with 2N aqueous sodium hydroxide and with brine, dried over magnesium sulfate and evaporated under reduced pressure. The residual material was triturated with dichloromethane, insoluble material was filtered off, and the filtrate was evaporated under reduced pressure to afford the title compound (128 mg, 92%) as orange oil.

Provenance & Evidence