Methyl 4-amino-2-fluorobenzoate → HCID 68631643, compound

HRID 1855385Notes

Reaction equation

HRID 1855385 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=1.[CH2:13]([C:20]1[CH:25]=[C:24]([CH3:26])[N:23]=[C:22](Cl)[N:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([C:20]1[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([NH:1][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=2)[N:21]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 21957875Methyl 4-amino-2-fluorobenzoateHCID 866336184-Benzyl-2-chloro-6-methyl-pyrimidine

Product 1

HCID 68631643HCID 68631643, compound

Procedure

The title compound was prepared from methyl 4-amino-2-fluoro-benzoate (480 mg, 2.84 mmol) and 4-benzyl-2-chloro-6-methyl-pyrimidine (620 mg, 2.84 mmol) in the same manner as described for example 1e). Obtained as white solid (840 mg, 84%). Mp 148-151° C.

Sources & evidence

ORD record
ord-5e5c8ab912ac498db7bea25e0906c5f3
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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