HCID 53928115, compound → HCID 57829760, compound

HRID 1855387Notes

Reaction equation

HRID 1855387 reaction equation
[Cl:1][C:2]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:3]=1[C:4]([C:6](=[CH:12]N(C)C)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=O.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([NH:43][C:44]([NH2:46])=[NH:45])[CH:34]=[CH:35][C:36]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1>>[Cl:1][C:2]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:3]=1[C:4]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:12][N:46]=[C:44]([NH:43][C:33]2[CH:34]=[CH:35][C:36]([N:37]3[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]3)=[C:31]([O:30][CH3:29])[CH:32]=2)[N:45]=1

Participants

3

Reactant 2

HCID 53928115HCID 53928115, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57829760HCID 57829760, compound

Procedure

The title compound was prepared from crude ethyl 2-(2-chloro-4-fluoro-benzoyl)-3-dimethylamino-acrylate (50 mg, 0.17 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (51 mg, 0.14 mmol) using in analogous manner the procedure described in example 28b). Obtained as a yellow solid (14 mg, 21%).

Sources & evidence

ORD record
ord-34e45976f3cc42a1993bf9ac1ac85a1d
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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