tert-Butoxy bis(dimethylamino)methane → HCID 68914440, compound

HRID 1855395Notes

Reaction equation

HRID 1855395 reaction equation
[OH:1][C:2]([C:7]1[O:11][N:10]=[C:9]([CH3:12])[N:8]=1)([CH3:6])[C:3](=[O:5])[CH3:4].C(O[CH:18](N(C)C)[N:19]([CH3:21])[CH3:20])(C)(C)C>>[CH3:18][N:19]([CH3:21])[CH:20]=[CH:4][C:3](=[O:5])[C:2]([OH:1])([C:7]1[O:11][N:10]=[C:9]([CH3:12])[N:8]=1)[CH3:6]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 68639801HCID 68639801, compound

Product 1

HCID 68914440HCID 68914440, compound

Procedure

3-Hydroxy-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-butan-2-one (see example 58a) (102 mg, 0.6 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (138 mg) as a yellow oil which was used directly in the next step.

Sources & evidence

ORD record
ord-bdeac8616d2b4ce79ba002785e35bf45
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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