HCID 68638970, compound → HCID 57829789, compound

HRID 1855396Notes

Reaction equation

HRID 1855396 reaction equation
CN(C)[CH:3]=[CH:4][C:5](=O)[C:6]([CH3:14])([C:8]1[O:12][N:11]=[C:10]([CH3:13])[N:9]=1)C.[N+]([O-])(O)=[O:18].[N+]([O-])(O)=O.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([NH:39][C:40]([NH2:42])=[NH:41])[CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1>>[CH3:25][O:26][C:27]1[CH:28]=[C:29]([NH:39][C:40]2[N:42]=[C:5]([C:6]([C:8]3[O:12][N:11]=[C:10]([CH3:13])[N:9]=3)([OH:18])[CH3:14])[CH:4]=[CH:3][N:41]=2)[CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1

Participants

3

Reactant 2

HCID 68638970HCID 68638970, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57829789HCID 57829789, compound

Procedure

The title compound was prepared from crude 1-dimethylamino-4-methyl-4-(3-methyl-[1,2,4]oxadiazol-5-yl)-pent-1-en-3-one (138 mg, 0.6 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (185 mg, 0.5 mmol) using in analogous manner the procedure described in example 39b). Obtained as a pale-yellow solid (32 mg, 16%);

Sources & evidence

ORD record
ord-1c80808f3e624fb3ad53819cac2b7d26
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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