Pyrimidine, 4-chloro-6-(4-chlorophenoxy)- → HCID 57829736, compound

HRID 1855399Notes

Reaction equation

HRID 1855399 reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([NH2:30])[CH:21]=[CH:22][C:23]=1[N:24]1[CH:28]=[C:27]([CH3:29])[N:26]=[CH:25]1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:30][C:20]3[CH:21]=[CH:22][C:23]([N:24]4[CH:28]=[C:27]([CH3:29])[N:26]=[CH:25]4)=[C:18]([O:17][CH3:16])[CH:19]=3)[CH:7]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 3079025Pyrimidine, 4-chloro-6-(4-chlorophenoxy)-HCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 57829736HCID 57829736, compoundYield 18%

Conditions

Temperature
200 °C

Procedure

The title compound was prepared from 4-chloro-6-(4-chloro-phenoxy)-pyrimidine and 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine in analogous manner as described in example 62 by heating the reaction mixture in a microwave oven at 200° C. for 2.5 h. Obtained as a yellow solid in 18% yield.

Workup

  1. customObtained as a yellow solid in 18% yield

Sources & evidence

ORD record
ord-5341d12799be48b58333200bfa764a32
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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