Sodium Hydroxide → HCID 86633619, compound

Participants

Reaction Conditions

Reaction Steps

To 6-[1-(4-chlorophenyl)cyclobutyl]-2-methylpyrimidin-4-ol (1.00 g, 3.65 mmol) was added phosphorous oxychloride (10 mL) and the mixture was refluxed for 1.5 h. After cooling to 20° C., the reaction mixture was poured into ice/water (55 mL). After the addition of dichloromethane, the mixture was neutralized with 32% aqueous sodium hydroxide solution. The layers were separated and the organic layer was washed with 0.1 N sodium hydroxide solution and with water, dried over magnesium sulfate, and evaporated under reduced pressure. The residual material was purified by chromatography on silica gel using dichloromethane/methanol (95:5 v/v) as eluent to afford the title compound (0.91 g, 85%) as an off-white solid. Mp 96-98° C.

Provenance & Evidence