3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline → HCID 44192795, compound

HRID 1855403Notes

Reaction equation

HRID 1855403 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[CH2:11][CH2:10][CH2:9]2)[N:5]=[C:4]([CH3:19])[N:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH2:34])[CH:25]=[CH:26][C:27]=1[N:28]1[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:8]2([C:6]3[N:5]=[C:4]([CH3:19])[N:3]=[C:2]([NH:34][C:24]4[CH:25]=[CH:26][C:27]([N:28]5[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]5)=[C:22]([O:21][CH3:20])[CH:23]=4)[CH:7]=3)[CH2:11][CH2:10][CH2:9]2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)anilineHCID 86633619HCID 86633619, compound

Product 1

HCID 44192795HCID 44192795, compoundYield 81%

Procedure

The title compound was prepared in analogous manner as described in example 62 from 4-chloro-6-[1-(4-chloro-phenyl)-cyclobutyl]-2-methyl-pyrimidine and 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine Obtained as a pale-yellow solid in 81% yield after column chromatography of the crude product on silica gel using dichloromethane/methanol (19:1 v/v) as eluent.

Sources & evidence

ORD record
ord-ce71a092806940a897b59ab4c2ddc079
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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